Search by:
Year of publication
Author name
Paper title
Model of the immunosensor on the basis of difference equations on a hexagonal lattice
Full text (PDF)
UDC: 602.1:519.85:53.082.9:616-07
Publication Language: Ukrainian
Stuc. intelekt. 2018; 23(3):132-140
Abstract: The model of the immunosensor, which is based on the system of difference equations on a hexagonal lattice, is proposed in the paper. A class of solvable differential equations with time delay was introduced for modeling the interaction of antigen-antibodies within immunopicles. The construction of the model is based on a number of biological assumptions about the interaction of colonies of antigens and antibodies, as well as the diffusion of antigens. To describe the discrete spaces in the space of the colonies localized in the corresponding pixels, the apparatus of difference differential equations on a hexagonal lattice is used.
Keywords:
References:
- Mosinska, L., Fabisiak, K., Paprocki, K.,Kowalska, M., Popielarski, P., Szybowicz, M.,Stasiak, A. (2013) Diamond as a transducermaterial for the production of biosensors.Przemysl Chemiczny, vol. 92, no. 6, pp. 919–923.
- Adley, C. (2014) Past, present and future ofsensors in food production. Foods, vol. 3, no. 3,pp. 491–510. doi: 10. 3390 / foods3030491.[Online]. Available: https://doi.org/10.3390/foods3030491.
- Kłos-Witkowska, A. (2015) Enzyme-basedfluorescent biosensors and their environmental,clinical and industrial applications. Polish Journalof Environmental Studies, vol. 24, pp. 19–25. doi:10.15244/pjoes/28352. [Online]. Available:https://doi.org/10.15244/pjoes/28352.
- Burnworth, M., Rowan, S., Weder, C. (2007)Fluorescent sensors for the detection of chemicalwarfare agents. Chemistry - A European Journal,vol. 13, no. 28, pp. 7828–7836. doi:10.1002/chem.200700720. [Online]. Available:https://doi.org/10.1002/chem.200700720.
- Mehrotra, P. (2016) Biosensors and theirapplications – a review. Journal of Oral Biologyand Craniofacial Research, vol. 6, no. 2, pp. 153–159. doi: 10.1016/j.jobcr.2015. 12.002. [Online].Available:https://doi.org/10.1016/j.jobcr.2015.12.002.
- Martsenyuk, V.P., Klos-Witkowska, A.,Sverstiuk, A.S. (2018) Study of classification ofimmunosensors from viewpoint of medical tasks.Medical informatics and engineering. № 1(41). –p. 13-19. DOI: https://dx.doi.org/10.11603/mie.1996-1960.2018.1.8887.
- Martsenyuk, V.P., Klos-Witkowska, A.,Sverstiuk, A.S., Bihunyak, T.V. (2018) Onprinciples, methods and areas of medical andbiological application of optical immunosensors.Medical informatics and engineering. № 2 (42). –p.28-36. DOI: https://dx.doi.org/10.11603/mie.1996-1960.2018.2.9289.
- Moina, C., Ybarra, G. (2012) Fundamentals andapplications of immunosensors. Advances inimmunoassay technology, pp. 65–80.
- Kłos-Witkowska, A. (2016) The phenomenon offluorescence in immunosensors. Acta BiochimicaPolonica, vol. 63, no. 2, pp. 215–221, 2016. doi:
- 18388/abp.2015_1231. [Online]. Available:https://doi.org/10.18388/abp.2015_1231.10. Marzeniuk, V. Taking into account delay in theproblem of immune protection of organism.Nonlinear Analysis: Real World Applications,vol. 2, no. 4, pp. 483–496, 2001, cited By 2. doi:10.1016/S1468-1218(01)00005-0. [Online]. Available:https://www.scopus.com/inward/record.uri?eid=2-s2.0-0041331752&doi=10.1016%2fS1468-1218%2801%2900005-0&partnerID=40&md5=9943d225f352151e77407b48b18ab1a9.
- Prindle, A., Samayoa, P., Razinkov, I.,Danino, T., Tsimring, L.S., Hasty, J. (2011)A sensing array of radically coupled genetic‘biopixels’. Nature, vol. 481, no. 7379, pp. 39–44.doi: 10 .1038/ nature10722. [Online]. Available:https : // doi . org/ 10 .1038/nature10722.
- Gibson, T.D. (1999) Biosensors: The stabilitéproblem. Analusis, vol. 27, no. 7, pp. 630–638.
- Kuang, Y. (1993) Delay differential equationswith applications in population dynamics. NewYork: Academic Press.
- Niu, H. (2015) Spreading speeds in a latticedifferential equation with distributed delay.Turkish Journal of Mathematics, vol. 39, no. 2,pp. 235–250.
- Hoffman, A., Hupkes, H., Vleck E.V. (2017)Entire solutions for bistable lattice differentialequations with obstacles.
- Martsenyuk, V.P., Sverstiuk, A.S. (2018) Modelimunosensora na osnovi reshitchastykhdyferentsialnykh rivnian iz zapiznenniam.Shtuchnyi intelekt, № 1. S. 42-47.
- [Online]. Available:https://www.redblobgames.com/grids/hexagons/.
- McCluskey, C.C. (2010) Complete globalstability for an SIR epidemic model with delay –distributed or discrete. Nonlinear Analysis: RealWorld Applications, vol. 11, no. 1, pp. 55–59. doi:10.1016/j.nonrwa.2008.10.014. [Online].Available: https://doi.org/10.1016/j.nonrwa.2008.10.014.
- Liu, L., Liu, Z. (2011) Asymptotic behaviors of adelayed nonautonomous predator-prey systemgoverned by difference equations. DiscreteDynamics in Nature and Society, vol. 2011,pp. 1–15. doi: 10 . 1155 / 2011 / 271928.[Online]. Available:https://doi.org/10.1155/2011/271928.
- Letellier, C., Elaydi, S., Aguirre, L.A., Alaoui, A.(2004) Difference equations versus differentialequations, a possible equivalence for the r¨osslersystem? Physica D: Nonlinear Phenomena,vol. 195, no. 1-2, pp. 29–49.doi: 10.1016/j.physd.2004.02.007. [Online].Available: https://doi.org/10.1016/j.physd.2004.02.007.
- Mickens, R.E. (1994) Nonstandard finitedifference models of differential equations. worldscientific.
- Jang, S., Elaydi, S. (2003) Difference equationsfrom discretization of a continuous epidemicmodel with immigration of infectives.